The present investigation evaluate the antidiabetic effect of Citrullus colocynthis on liver hexokinase and gluconeogenic enzymes such as glucose-6-phosphatase and fructose 1, 6-bisphosphatase in the liver of control and alloxan-diabetic rats. Oral administration of leaf suspension of Citrullus colocynthis (250mg and 500mg /kg body weight) for 60 days resulted in momentous reduction in blood glucose (from 381 ± 34 to 105 ± 35), glycosylated hemoglobin, a decrease in the activities of glucose-6 phosphatase and fructose 1, 6-bisphosphatase, and an increase in the activity of liver hexokinase. The findings of study support the antidiabetic asserts of Citrullus colocynthis.
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